Drug interactions
Pitavastatin + Pretomanid
Severity: Minor
Pitavastatin and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro and may raise exposure to sensitive substrates. Pitavastatin is mainly an OATP1B1 substrate, so any effect is probably small.
What this interaction means in plain words
Pitavastatin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pitavastatin belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Pretomanid may inhibit OATP1B3, which could slightly increase pitavastatin uptake-dependent exposure.
What to do
No dose change is needed. Advise patients to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Pitavastatin with Pretomanid?
MediHelp rates the interaction as minor. Pitavastatin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3 in vitro and may raise exposure to sensitive substrates. Pitavastatin is mainly an OATP1B1 substrate, so any effect is probably small.
How serious is the interaction between Pitavastatin and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Advise patients to report muscle pain or weakness.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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