Drug interactions
Pitolisant + Ribociclib
Severity: Major
Pitolisant and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias. Pitolisant labeling cautions against use with other QT-prolonging drugs.
What this interaction means in plain words
Pitolisant and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pitolisant belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid the pair when possible; if needed, obtain baseline and follow-up ECGs, correct electrolytes, and stop or reduce a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Ribociclib?
MediHelp rates the interaction as major. Pitolisant and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias. Pitolisant labeling cautions against use with other QT-prolonging drugs.
How serious is the interaction between Pitolisant and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the pair when possible; if needed, obtain baseline and follow-up ECGs, correct electrolytes, and stop or reduce a drug if QTc becomes markedly prolonged.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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