Drug interactions
Pitolisant + Solifenacin
Severity: Moderate
Pitolisant and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can modestly prolong the QT interval and solifenacin may add to this effect. Pitolisant is also a weak CYP3A4 inducer, and anticholinergics may reduce its effect since pitolisant acts via histamine H3 receptors.
What this interaction means in plain words
Pitolisant and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with possible pharmacodynamic opposition from antihistaminic or anticholinergic activity.
What to do
Monitor ECG in patients with other QT risk factors and reassess pitolisant efficacy. Consider an alternative bladder agent if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Solifenacin?
MediHelp rates the interaction as moderate. Pitolisant and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can modestly prolong the QT interval and solifenacin may add to this effect. Pitolisant is also a weak CYP3A4 inducer, and anticholinergics may reduce its effect since pitolisant acts via histamine H3 receptors.
How serious is the interaction between Pitolisant and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with other QT risk factors and reassess pitolisant efficacy. Consider an alternative bladder agent if QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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