Drug interactions
Pneumococcal vaccine 13-valent + Procarbazine
Severity: Moderate
Pneumococcal vaccine 13-valent and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine-induced immunosuppression may weaken the antibody response to the conjugate pneumococcal vaccine. Patients may remain susceptible to pneumococcal infection despite vaccination.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
Immunosuppression from procarbazine blunts the vaccine immune response.
What to do
Give the vaccine at least 2 weeks before starting procarbazine when possible. If vaccinated during therapy, plan revaccination after chemotherapy is complete and immune recovery has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Procarbazine?
MediHelp rates the interaction as moderate. Pneumococcal vaccine 13-valent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine-induced immunosuppression may weaken the antibody response to the conjugate pneumococcal vaccine. Patients may remain susceptible to pneumococcal infection despite vaccination.
How serious is the interaction between Pneumococcal vaccine 13-valent and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before starting procarbazine when possible. If vaccinated during therapy, plan revaccination after chemotherapy is complete and immune recovery has occurred.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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