Drug interactions
Pneumococcal vaccine 13-valent + Ustekinumab
Severity: Minor
Pneumococcal vaccine 13-valent and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt immune responses to vaccines, although inactivated vaccines are not contraindicated. Protective antibody levels may be lower than expected in treated patients.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
IL-12/23 inhibition may modestly attenuate immune response to vaccine antigens.
What to do
Give recommended inactivated vaccines, ideally before starting ustekinumab when feasible, and follow standard schedules without delaying needed therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Ustekinumab?
MediHelp rates the interaction as minor. Pneumococcal vaccine 13-valent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt immune responses to vaccines, although inactivated vaccines are not contraindicated. Protective antibody levels may be lower than expected in treated patients.
How serious is the interaction between Pneumococcal vaccine 13-valent and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give recommended inactivated vaccines, ideally before starting ustekinumab when feasible, and follow standard schedules without delaying needed therapy.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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