Drug interactions
Pneumococcal vaccine 13-valent + Voclosporin
Severity: Moderate
Pneumococcal vaccine 13-valent and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that suppresses T-cell activity and may reduce the immune response to pneumococcal conjugate vaccine. The vaccine remains safe but may be less effective.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent antibody responses.
What to do
Vaccinate before starting voclosporin when possible. If given during therapy, consider checking antibody response or revaccinating after immunosuppression is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Voclosporin?
MediHelp rates the interaction as moderate. Pneumococcal vaccine 13-valent and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that suppresses T-cell activity and may reduce the immune response to pneumococcal conjugate vaccine. The vaccine remains safe but may be less effective.
How serious is the interaction between Pneumococcal vaccine 13-valent and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting voclosporin when possible. If given during therapy, consider checking antibody response or revaccinating after immunosuppression is reduced.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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