Drug interactions
Pneumococcal vaccine heptavalent + Temsirolimus
Severity: Moderate
Pneumococcal vaccine heptavalent and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may lessen the antibody response to pneumococcal conjugate vaccine. Patients with cancer are at higher risk of pneumococcal disease, so reduced protection matters.
What this interaction means in plain words
Pneumococcal vaccine heptavalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition impairs T- and B-cell responses to vaccine antigens.
What to do
Vaccinate before starting temsirolimus if possible. Still vaccinate during therapy if indicated, and consider revaccination per guidelines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine heptavalent with Temsirolimus?
MediHelp rates the interaction as moderate. Pneumococcal vaccine heptavalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may lessen the antibody response to pneumococcal conjugate vaccine. Patients with cancer are at higher risk of pneumococcal disease, so reduced protection matters.
How serious is the interaction between Pneumococcal vaccine heptavalent and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting temsirolimus if possible. Still vaccinate during therapy if indicated, and consider revaccination per guidelines.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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