Drug interactions
Pneumococcal vaccine polyvalent + Temsirolimus
Severity: Moderate
Pneumococcal vaccine polyvalent and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may reduce the antibody response to polysaccharide pneumococcal vaccine, leaving at-risk patients less protected. The vaccine is non-live and carries no infection risk.
What this interaction means in plain words
Pneumococcal vaccine polyvalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR-mediated immunosuppression lowers vaccine-induced antibody production.
What to do
Give before temsirolimus where feasible. If given during therapy, follow guideline-based revaccination timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pneumococcal vaccine polyvalent and Temsirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine polyvalent with Temsirolimus?
MediHelp rates the interaction as moderate. Pneumococcal vaccine polyvalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may reduce the antibody response to polysaccharide pneumococcal vaccine, leaving at-risk patients less protected. The vaccine is non-live and carries no infection risk.
How serious is the interaction between Pneumococcal vaccine polyvalent and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give before temsirolimus where feasible. If given during therapy, follow guideline-based revaccination timing.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
