Drug interactions
Pomalidomide + Quinine
Severity: Minor
Pomalidomide and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein, which could modestly increase pomalidomide exposure. The clinical significance is likely limited because pomalidomide is mainly cleared by metabolism.
What this interaction means in plain words
Pomalidomide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
Why it happens
Quinine inhibits P-glycoprotein efflux of pomalidomide, a weak substrate.
What to do
No dose change is usually needed; monitor for pomalidomide adverse effects such as myelosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Quinine?
MediHelp rates the interaction as minor. Pomalidomide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine inhibits P-glycoprotein, which could modestly increase pomalidomide exposure. The clinical significance is likely limited because pomalidomide is mainly cleared by metabolism.
How serious is the interaction between Pomalidomide and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for pomalidomide adverse effects such as myelosuppression.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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