Drug interactions
Pomalidomide + Tamoxifen
Severity: Moderate
Pomalidomide and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen inhibits P-glycoprotein and may modestly raise pomalidomide exposure. Both drugs increase the risk of venous thromboembolism, so combined use adds to this risk.
What this interaction means in plain words
Pomalidomide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pomalidomide belongs to Miscellaneous; Tamoxifen belongs to Endocrine.
Why it happens
P-gp inhibition by tamoxifen may raise pomalidomide levels, with additive prothrombotic effects.
What to do
Assess thrombosis risk and give thromboprophylaxis as indicated. Monitor for pomalidomide toxicity such as neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Tamoxifen?
MediHelp rates the interaction as moderate. Pomalidomide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen inhibits P-glycoprotein and may modestly raise pomalidomide exposure. Both drugs increase the risk of venous thromboembolism, so combined use adds to this risk.
How serious is the interaction between Pomalidomide and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess thrombosis risk and give thromboprophylaxis as indicated. Monitor for pomalidomide toxicity such as neutropenia.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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