Drug interactions
Pomalidomide + Tolvaptan
Severity: Minor
Pomalidomide and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro, and pomalidomide is a P-gp substrate. A clinically meaningful rise in pomalidomide exposure is theoretical and not well documented.
What this interaction means in plain words
Pomalidomide and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Possible inhibition of P-gp efflux of pomalidomide by tolvaptan.
What to do
No routine change is needed. Monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Tolvaptan?
MediHelp rates the interaction as minor. Pomalidomide and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro, and pomalidomide is a P-gp substrate. A clinically meaningful rise in pomalidomide exposure is theoretical and not well documented.
How serious is the interaction between Pomalidomide and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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