Drug interactions
Ponatinib + Ranolazine
Severity: Moderate
Ponatinib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may inhibit P-glycoprotein and OATP1B1, which could increase ranolazine exposure. Higher ranolazine levels can add to dose-related QT prolongation, dizziness and nausea, and ponatinib itself carries cardiovascular and QT concerns.
What this interaction means in plain words
Ponatinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Ponatinib inhibition of P-gp and possibly hepatic uptake transporters, raising ranolazine concentrations.
What to do
Monitor ECG and for ranolazine adverse effects such as dizziness, nausea and bradycardia. Reduce the ranolazine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Ranolazine?
MediHelp rates the interaction as moderate. Ponatinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may inhibit P-glycoprotein and OATP1B1, which could increase ranolazine exposure. Higher ranolazine levels can add to dose-related QT prolongation, dizziness and nausea, and ponatinib itself carries cardiovascular and QT concerns.
How serious is the interaction between Ponatinib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for ranolazine adverse effects such as dizziness, nausea and bradycardia. Reduce the ranolazine dose if adverse effects occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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