Drug interactions
Ponatinib + Temsirolimus
Severity: Moderate
Ponatinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and may raise exposure to temsirolimus and its active metabolite sirolimus. This could increase mTOR-related adverse effects such as mucositis, cytopenias, hyperglycemia, hyperlipidemia and pneumonitis.
What this interaction means in plain words
Ponatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Ponatinib inhibits P-glycoprotein efflux, potentially reducing elimination of temsirolimus.
What to do
Monitor for temsirolimus toxicity such as mucositis, cytopenias, hyperglycemia and pneumonitis. Reduce the temsirolimus dose or interrupt treatment if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ponatinib and Temsirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Temsirolimus?
MediHelp rates the interaction as moderate. Ponatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and may raise exposure to temsirolimus and its active metabolite sirolimus. This could increase mTOR-related adverse effects such as mucositis, cytopenias, hyperglycemia, hyperlipidemia and pneumonitis.
How serious is the interaction between Ponatinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity such as mucositis, cytopenias, hyperglycemia and pneumonitis. Reduce the temsirolimus dose or interrupt treatment if adverse effects emerge.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
