Drug interactions
Potassium iodide + Sacubitril-valsartan
Severity: Moderate
Potassium iodide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies potassium and, when taken with an angiotensin receptor blocker, can contribute to hyperkalemia. Short courses carry limited risk, but longer or repeated use is more concerning, especially in renal impairment.
What this interaction means in plain words
Potassium iodide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Potassium iodide belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Potassium load combined with reduced aldosterone-mediated renal potassium excretion.
What to do
Monitor serum potassium if potassium iodide is used for more than a brief period, especially in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Potassium iodide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Potassium iodide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies potassium and, when taken with an angiotensin receptor blocker, can contribute to hyperkalemia. Short courses carry limited risk, but longer or repeated use is more concerning, especially in renal impairment.
How serious is the interaction between Potassium iodide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if potassium iodide is used for more than a brief period, especially in patients with reduced renal function.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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