Drug interactions
Potassium iodide + Trandolapril
Severity: Moderate
Potassium iodide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide provides a potassium load, and ACE inhibitors impair potassium excretion through reduced aldosterone. Hyperkalemia may result, particularly with renal impairment or prolonged use.
What this interaction means in plain words
Potassium iodide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Potassium iodide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone-mediated potassium excretion while potassium iodide adds potassium.
What to do
Monitor serum potassium and renal function if potassium iodide is given for more than a short course. Avoid prolonged use in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Potassium iodide with Trandolapril?
MediHelp rates the interaction as moderate. Potassium iodide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide provides a potassium load, and ACE inhibitors impair potassium excretion through reduced aldosterone. Hyperkalemia may result, particularly with renal impairment or prolonged use.
How serious is the interaction between Potassium iodide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if potassium iodide is given for more than a short course. Avoid prolonged use in patients with renal impairment.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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