Drug interactions
Pralatrexate + Sulindac
Severity: Moderate
Pralatrexate and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal clearance of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression. The effect is most relevant in patients with reduced renal function.
What this interaction means in plain words
Pralatrexate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pralatrexate belongs to Oncology; Sulindac belongs to Musculoskeletal.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal perfusion delay pralatrexate elimination.
What to do
Monitor for pralatrexate toxicity (mucositis, blood counts) and renal function, and adjust the pralatrexate dose per labeling if toxicity develops. Consider avoiding NSAIDs where an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Pralatrexate with Sulindac?
MediHelp rates the interaction as moderate. Pralatrexate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the renal clearance of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression. The effect is most relevant in patients with reduced renal function.
How serious is the interaction between Pralatrexate and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pralatrexate toxicity (mucositis, blood counts) and renal function, and adjust the pralatrexate dose per labeling if toxicity develops. Consider avoiding NSAIDs where an alternative exists.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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