Drug interactions
Pramipexole + Quinidine
Severity: Moderate
Pramipexole and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole is cleared mainly by renal tubular secretion through the cationic transport pathway. Quinidine may compete for this pathway and raise pramipexole exposure. This can increase dopaminergic effects such as dizziness, somnolence, hallucinations and dyskinesia.
What this interaction means in plain words
Pramipexole and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pramipexole belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal cationic transport reduces the renal clearance of pramipexole.
What to do
Monitor for dopaminergic adverse effects such as sedation, dizziness and hallucinations. Consider reducing the pramipexole dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Pramipexole with Quinidine?
MediHelp rates the interaction as moderate. Pramipexole and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pramipexole is cleared mainly by renal tubular secretion through the cationic transport pathway. Quinidine may compete for this pathway and raise pramipexole exposure. This can increase dopaminergic effects such as dizziness, somnolence, hallucinations and dyskinesia.
How serious is the interaction between Pramipexole and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects such as sedation, dizziness and hallucinations. Consider reducing the pramipexole dose if they occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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