Drug interactions
Pramipexole + Tafenoquine
Severity: Moderate
Pramipexole and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole is eliminated mainly by renal tubular secretion through OCT2 and MATE transporters, which tafenoquine inhibits in vitro. Exposure to pramipexole may therefore rise, increasing dopaminergic adverse effects.
What this interaction means in plain words
Pramipexole and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pramipexole belongs to Cardiovascular; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE renal transporters, reducing pramipexole renal clearance.
What to do
Monitor for nausea, dyskinesia, hallucinations and somnolence. Reduce the pramipexole dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Pramipexole with Tafenoquine?
MediHelp rates the interaction as moderate. Pramipexole and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pramipexole is eliminated mainly by renal tubular secretion through OCT2 and MATE transporters, which tafenoquine inhibits in vitro. Exposure to pramipexole may therefore rise, increasing dopaminergic adverse effects.
How serious is the interaction between Pramipexole and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, dyskinesia, hallucinations and somnolence. Reduce the pramipexole dose if adverse effects appear.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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