Drug interactions
Pramipexole + Trilaciclib
Severity: Moderate
Pramipexole and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2 and MATE transporters, which handle renal secretion of pramipexole. Pramipexole levels may increase, with more dopaminergic adverse effects.
What this interaction means in plain words
Pramipexole and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pramipexole belongs to Cardiovascular; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2/MATE1/MATE2-K transport, reducing pramipexole renal clearance.
What to do
Monitor for pramipexole adverse effects such as somnolence, hallucinations and dyskinesia around trilaciclib doses. Reduce the pramipexole dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Pramipexole with Trilaciclib?
MediHelp rates the interaction as moderate. Pramipexole and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2 and MATE transporters, which handle renal secretion of pramipexole. Pramipexole levels may increase, with more dopaminergic adverse effects.
How serious is the interaction between Pramipexole and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pramipexole adverse effects such as somnolence, hallucinations and dyskinesia around trilaciclib doses. Reduce the pramipexole dose if needed.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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