Drug interactions
Prasugrel + Sulindac
Severity: Major
Prasugrel and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent antiplatelet agent and sulindac adds platelet inhibition and gastrointestinal mucosal injury. Together they raise the risk of significant bleeding, especially gastrointestinal.
What this interaction means in plain words
Prasugrel and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prasugrel belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function (P2Y12 blockade plus COX inhibition) with NSAID-related mucosal damage.
What to do
Avoid regular NSAID use with prasugrel where possible and use paracetamol for analgesia. If unavoidable, monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Prasugrel with Sulindac?
MediHelp rates the interaction as major. Prasugrel and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet agent and sulindac adds platelet inhibition and gastrointestinal mucosal injury. Together they raise the risk of significant bleeding, especially gastrointestinal.
How serious is the interaction between Prasugrel and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with prasugrel where possible and use paracetamol for analgesia. If unavoidable, monitor for bleeding and consider gastroprotection.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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