Drug interactions
Pravastatin + Sacubitril-valsartan
Severity: Minor
Pravastatin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril inhibits OATP1B1/1B3, which carry pravastatin into the liver, so statin exposure may rise modestly. Higher levels could slightly increase the risk of muscle-related adverse effects.
What this interaction means in plain words
Pravastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Sacubitril inhibition of hepatic OATP1B1/1B3 uptake of pravastatin.
What to do
No routine dose change is needed; counsel patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Pravastatin
Frequently asked questions
Can I take Pravastatin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Pravastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril inhibits OATP1B1/1B3, which carry pravastatin into the liver, so statin exposure may rise modestly. Higher levels could slightly increase the risk of muscle-related adverse effects.
How serious is the interaction between Pravastatin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel patients to report unexplained muscle pain or weakness.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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