Drug interactions
Pravastatin + Saquinavir
Severity: Moderate
Pravastatin and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually boosted with ritonavir, may alter pravastatin exposure and increase myopathy risk. Pravastatin is generally the safer statin option with this agent.
What this interaction means in plain words
Pravastatin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible OATP1B1 inhibition reducing hepatic uptake of pravastatin.
What to do
Start pravastatin at a low dose, titrate to response, and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Pravastatin with Saquinavir?
MediHelp rates the interaction as moderate. Pravastatin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually boosted with ritonavir, may alter pravastatin exposure and increase myopathy risk. Pravastatin is generally the safer statin option with this agent.
How serious is the interaction between Pravastatin and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pravastatin at a low dose, titrate to response, and monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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