Drug interactions
Pravastatin + Telmisartan-amlodipine
Severity: Minor
Pravastatin and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may inhibit OATP1B1 in vitro, which could theoretically increase pravastatin exposure. Any clinically relevant effect on muscle toxicity is not established.
What this interaction means in plain words
Pravastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of pravastatin by telmisartan.
What to do
No dose adjustment is usually required; advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Pravastatin
Frequently asked questions
Can I take Pravastatin with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Pravastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan may inhibit OATP1B1 in vitro, which could theoretically increase pravastatin exposure. Any clinically relevant effect on muscle toxicity is not established.
How serious is the interaction between Pravastatin and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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