Drug interactions
Praziquantel + Ribociclib
Severity: Minor
Praziquantel and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise praziquantel concentrations, potentially increasing dizziness, drowsiness and gastrointestinal effects. Praziquantel is typically given as a short course, limiting the clinical impact.
What this interaction means in plain words
Praziquantel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Praziquantel belongs to Anti Parasitic; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing praziquantel metabolism.
What to do
Counsel on dizziness and avoid driving after praziquantel doses. No dose change is generally needed for a short course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Praziquantel with Ribociclib?
MediHelp rates the interaction as minor. Praziquantel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4 and may raise praziquantel concentrations, potentially increasing dizziness, drowsiness and gastrointestinal effects. Praziquantel is typically given as a short course, limiting the clinical impact.
How serious is the interaction between Praziquantel and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness and avoid driving after praziquantel doses. No dose change is generally needed for a short course.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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