Drug interactions
Praziquantel + Tecovirimat
Severity: Minor
Praziquantel and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower praziquantel exposure. Any reduction in effect is likely small but could matter for efficacy.
What this interaction means in plain words
Praziquantel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Praziquantel belongs to Anti Parasitic; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly induces CYP3A4, increasing praziquantel clearance.
What to do
No dose adjustment is routinely needed; assess clinical response to praziquantel and repeat treatment if there is evidence of failure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Praziquantel and Tecovirimat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Praziquantel with Tecovirimat?
MediHelp rates the interaction as minor. Praziquantel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower praziquantel exposure. Any reduction in effect is likely small but could matter for efficacy.
How serious is the interaction between Praziquantel and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; assess clinical response to praziquantel and repeat treatment if there is evidence of failure.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
