Drug interactions
Prazosin + Sotalol
Severity: Moderate
Prazosin and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining the alpha-1 blocker prazosin with the beta-blocker sotalol produces additive blood pressure lowering. The first-dose hypotensive response to prazosin, including orthostatic hypotension and syncope, may be more pronounced or last longer.
What this interaction means in plain words
Prazosin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prazosin belongs to Genitourinary; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blunted reflex tachycardia from beta-blockade.
What to do
Start prazosin at a low dose at bedtime and monitor standing blood pressure and heart rate after initiation and dose changes. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Sotalol?
MediHelp rates the interaction as moderate. Prazosin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining the alpha-1 blocker prazosin with the beta-blocker sotalol produces additive blood pressure lowering. The first-dose hypotensive response to prazosin, including orthostatic hypotension and syncope, may be more pronounced or last longer.
How serious is the interaction between Prazosin and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime and monitor standing blood pressure and heart rate after initiation and dose changes. Counsel patients to rise slowly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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