Drug interactions
Prednisolone + Rosiglitazone
Severity: Moderate
Prednisolone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone raises blood glucose and can induce insulin resistance, which opposes the glucose-lowering action of rosiglitazone. Glycemic control may deteriorate during steroid courses, especially at higher doses. Both drugs can also cause fluid retention.
What this interaction means in plain words
Prednisolone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance.
What to do
Monitor blood glucose more often during and after corticosteroid therapy and adjust antidiabetic doses as needed. Watch for edema and heart failure signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Prednisolone with Rosiglitazone?
MediHelp rates the interaction as moderate. Prednisolone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone raises blood glucose and can induce insulin resistance, which opposes the glucose-lowering action of rosiglitazone. Glycemic control may deteriorate during steroid courses, especially at higher doses. Both drugs can also cause fluid retention.
How serious is the interaction between Prednisolone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during and after corticosteroid therapy and adjust antidiabetic doses as needed. Watch for edema and heart failure signs.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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