Drug interactions
Prednisolone + Succinylcholine
Severity: Moderate
Prednisolone and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with neuromuscular blockers have been linked to acute myopathy, mainly with prolonged use in critically ill patients. Steroids may also modify the response to neuromuscular blockade, leading to variable recovery.
What this interaction means in plain words
Prednisolone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive skeletal muscle toxicity; the exact mechanism is not fully established.
What to do
Limit the duration of neuromuscular blocker exposure and monitor neuromuscular function. Evaluate for persistent weakness and check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Succinylcholine
Frequently asked questions
Can I take Prednisolone with Succinylcholine?
MediHelp rates the interaction as moderate. Prednisolone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with neuromuscular blockers have been linked to acute myopathy, mainly with prolonged use in critically ill patients. Steroids may also modify the response to neuromuscular blockade, leading to variable recovery.
How serious is the interaction between Prednisolone and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of neuromuscular blocker exposure and monitor neuromuscular function. Evaluate for persistent weakness and check creatine kinase if myopathy is suspected.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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