Drug interactions
Prednisolone + Trastuzumab deruxtecan
Severity: Moderate
Prednisolone and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair host defenses, since the antibody-drug conjugate causes neutropenia and corticosteroids suppress immunity. Together they may increase infection risk. Corticosteroids are also used as premedication, so combined use is often intentional.
What this interaction means in plain words
Prednisolone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor blood counts and signs of infection, and use the lowest effective steroid dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Prednisolone with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Prednisolone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair host defenses, since the antibody-drug conjugate causes neutropenia and corticosteroids suppress immunity. Together they may increase infection risk. Corticosteroids are also used as premedication, so combined use is often intentional.
How serious is the interaction between Prednisolone and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection, and use the lowest effective steroid dose and duration.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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