Drug interactions
Prednisone + Repaglinide
Severity: Moderate
Prednisone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone raises blood glucose and antagonizes the effect of antidiabetic drugs such as repaglinide, which is the more relevant issue than any enzyme effect. A weak CYP3A4 induction effect on repaglinide is possible but minor.
What this interaction means in plain words
Prednisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced insulin resistance and hepatic glucose output, with possible minor CYP3A4 induction.
What to do
Monitor blood glucose closely when starting, adjusting or stopping prednisone and adjust the repaglinide dose or add other agents as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Prednisone with Repaglinide?
MediHelp rates the interaction as moderate. Prednisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone raises blood glucose and antagonizes the effect of antidiabetic drugs such as repaglinide, which is the more relevant issue than any enzyme effect. A weak CYP3A4 induction effect on repaglinide is possible but minor.
How serious is the interaction between Prednisone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, adjusting or stopping prednisone and adjust the repaglinide dose or add other agents as needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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