Drug interactions
Prednisone + Saxagliptin-metformin
Severity: Moderate
Prednisone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisone raises blood glucose and can reduce the effectiveness of saxagliptin and metformin. It is also a weak CYP3A4 inducer, but the main concern is hyperglycemia.
What this interaction means in plain words
Prednisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Glucocorticoids increase gluconeogenesis and insulin resistance, opposing the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor blood glucose during prednisone therapy and adjust antidiabetic therapy as needed; reduce doses again when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Prednisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisone raises blood glucose and can reduce the effectiveness of saxagliptin and metformin. It is also a weak CYP3A4 inducer, but the main concern is hyperglycemia.
How serious is the interaction between Prednisone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during prednisone therapy and adjust antidiabetic therapy as needed; reduce doses again when the steroid is tapered.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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