Drug interactions
Prednisone + Secobarbital
Severity: Moderate
Prednisone and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic drug-metabolizing enzymes, which can speed up the clearance of prednisolone, the active form of prednisone. This may reduce corticosteroid effect and lead to loss of disease control or adrenal insufficiency in dependent patients.
What this interaction means in plain words
Prednisone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital induces CYP3A4 and other hepatic enzymes, increasing the metabolism of prednisolone.
What to do
Monitor clinical response to prednisone and increase the dose if symptoms recur. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Prednisone with Secobarbital?
MediHelp rates the interaction as moderate. Prednisone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic drug-metabolizing enzymes, which can speed up the clearance of prednisolone, the active form of prednisone. This may reduce corticosteroid effect and lead to loss of disease control or adrenal insufficiency in dependent patients.
How serious is the interaction between Prednisone and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to prednisone and increase the dose if symptoms recur. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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