Drug interactions
Prednisone + Sulindac
Severity: Moderate
Prednisone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID increases the risk of gastric and duodenal ulceration and gastrointestinal bleeding. The risk is highest in older patients and those with prior ulcer disease.
What this interaction means in plain words
Prednisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
NSAIDs reduce protective prostaglandins in the gastric mucosa while corticosteroids impair mucosal healing, giving additive GI injury.
What to do
Avoid the combination where possible; otherwise add a proton pump inhibitor and use the lowest effective doses for the shortest time. Monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Prednisone with Sulindac?
MediHelp rates the interaction as moderate. Prednisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID increases the risk of gastric and duodenal ulceration and gastrointestinal bleeding. The risk is highest in older patients and those with prior ulcer disease.
How serious is the interaction between Prednisone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise add a proton pump inhibitor and use the lowest effective doses for the shortest time. Monitor for GI bleeding.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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