Drug interactions
Prednisone + Tolfenamic acid
Severity: Moderate
Prednisone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a corticosteroid with an NSAID raises the risk of peptic ulceration and gastrointestinal bleeding. The harm is additive and more likely in older or high-risk patients.
What this interaction means in plain words
Prednisone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of gastroprotective prostaglandins combined with corticosteroid impairment of mucosal healing.
What to do
Avoid the combination if possible, or add gastroprotection with a proton pump inhibitor and limit dose and duration. Monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Prednisone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Prednisone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a corticosteroid with an NSAID raises the risk of peptic ulceration and gastrointestinal bleeding. The harm is additive and more likely in older or high-risk patients.
How serious is the interaction between Prednisone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or add gastroprotection with a proton pump inhibitor and limit dose and duration. Monitor for GI bleeding.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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