Drug interactions
Prednisone + Vecuronium
Severity: Moderate
Prednisone and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers such as vecuronium are associated with acute quadriplegic myopathy, especially in critically ill patients on prolonged infusions. Weakness may delay ventilator weaning and recovery.
What this interaction means in plain words
Prednisone and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Vecuronium belongs to Musculoskeletal.
Why it happens
Additive skeletal muscle toxicity; exact mechanism of acute myopathy is not fully established.
What to do
Limit the duration of neuromuscular blockade and corticosteroid dose, and monitor neuromuscular function. Check creatine kinase if prolonged weakness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Vecuronium
Frequently asked questions
Can I take Prednisone with Vecuronium?
MediHelp rates the interaction as moderate. Prednisone and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers such as vecuronium are associated with acute quadriplegic myopathy, especially in critically ill patients on prolonged infusions. Weakness may delay ventilator weaning and recovery.
How serious is the interaction between Prednisone and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of neuromuscular blockade and corticosteroid dose, and monitor neuromuscular function. Check creatine kinase if prolonged weakness occurs.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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