Drug interactions
Prednisone + Verapamil
Severity: Minor
Prednisone and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and P-glycoprotein and may modestly increase exposure to corticosteroids such as prednisolone. Clinically, this is usually of limited significance at typical doses.
What this interaction means in plain words
Prednisone and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prednisone belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and P-glycoprotein, reducing corticosteroid clearance.
What to do
Monitor for corticosteroid adverse effects such as fluid retention and hyperglycemia during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Prednisone with Verapamil?
MediHelp rates the interaction as minor. Prednisone and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and P-glycoprotein and may modestly increase exposure to corticosteroids such as prednisolone. Clinically, this is usually of limited significance at typical doses.
How serious is the interaction between Prednisone and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as fluid retention and hyperglycemia during long-term combined use.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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