Drug interactions
Pregabalin + Quinapril
Severity: Major
Pregabalin and Quinapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as quinapril can cause angioedema, and pregabalin has also been reported to cause angioedema. Taken together, the risk of swelling of the face, lips, tongue or airway may be greater, with potential respiratory compromise.
What this interaction means in plain words
Pregabalin and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive risk of angioedema; ACE inhibitors raise bradykinin levels, while the mechanism with pregabalin is not well established.
What to do
Tell patients to stop the drugs and seek urgent care if swelling of the face, lips, tongue or throat occurs. Consider an alternative antihypertensive class if angioedema develops, and monitor closely when starting either drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Quinapril?
MediHelp rates the interaction as major. Pregabalin and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors such as quinapril can cause angioedema, and pregabalin has also been reported to cause angioedema. Taken together, the risk of swelling of the face, lips, tongue or airway may be greater, with potential respiratory compromise.
How serious is the interaction between Pregabalin and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell patients to stop the drugs and seek urgent care if swelling of the face, lips, tongue or throat occurs. Consider an alternative antihypertensive class if angioedema develops, and monitor closely when starting either drug.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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