Drug interactions
Pretomanid + Thioguanine
Severity: Major
Pretomanid and Thioguanine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid regimens are associated with hepatotoxicity, and thioguanine can also injure the liver. Combined use may increase the risk of significant liver injury.
What this interaction means in plain words
Pretomanid and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pretomanid belongs to Anti Bacterial; Thioguanine belongs to Oncology.
Why it happens
Additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Avoid the combination where possible. If unavoidable, monitor liver enzymes and bilirubin at baseline and regularly, and interrupt therapy if hepatotoxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioguanine
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Thioguanine?
MediHelp rates the interaction as major. Pretomanid and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid regimens are associated with hepatotoxicity, and thioguanine can also injure the liver. Combined use may increase the risk of significant liver injury.
How serious is the interaction between Pretomanid and Thioguanine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor liver enzymes and bilirubin at baseline and regularly, and interrupt therapy if hepatotoxicity develops.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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