Drug interactions
Primaquine + Probenecid
Severity: Minor
Primaquine and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may raise primaquine levels, and primaquine itself can cause hemolysis in patients with G6PD deficiency. Data supporting a clinically significant interaction are limited.
What this interaction means in plain words
Primaquine and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Primaquine belongs to Anti Parasitic; Probenecid belongs to Genitourinary.
Why it happens
Possible reduced renal tubular secretion of primaquine; the mechanism is not well established.
What to do
Screen for G6PD deficiency before primaquine and monitor hemoglobin and for hemolysis signs if both drugs are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Primaquine with Probenecid?
MediHelp rates the interaction as minor. Primaquine and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid may raise primaquine levels, and primaquine itself can cause hemolysis in patients with G6PD deficiency. Data supporting a clinically significant interaction are limited.
How serious is the interaction between Primaquine and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for G6PD deficiency before primaquine and monitor hemoglobin and for hemolysis signs if both drugs are used.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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