Drug interactions
Primaquine + Quetiapine
Severity: Moderate
Primaquine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can prolong the QT interval, especially in overdose or with other risk factors, and primaquine may add to this effect. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Primaquine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor the QTc and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Primaquine with Quetiapine?
MediHelp rates the interaction as moderate. Primaquine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can prolong the QT interval, especially in overdose or with other risk factors, and primaquine may add to this effect. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Primaquine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor the QTc and avoid additional QT-prolonging drugs.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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