Drug interactions
Primaquine + Sertraline
Severity: Moderate
Primaquine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a small QT-prolonging effect at usual doses, and primaquine may add to it. The combined risk is usually low but increases with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Primaquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG if the patient has cardiac disease or other QT risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Primaquine with Sertraline?
MediHelp rates the interaction as moderate. Primaquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a small QT-prolonging effect at usual doses, and primaquine may add to it. The combined risk is usually low but increases with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Primaquine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG if the patient has cardiac disease or other QT risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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