Drug interactions
Primaquine + Voclosporin
Severity: Moderate
Primaquine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmias. Voclosporin exposure can also be raised by other factors, compounding the risk.
What this interaction means in plain words
Primaquine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and repeat it during therapy, and maintain normal potassium and magnesium. Reassess the combination if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Primaquine with Voclosporin?
MediHelp rates the interaction as moderate. Primaquine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmias. Voclosporin exposure can also be raised by other factors, compounding the risk.
How serious is the interaction between Primaquine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and repeat it during therapy, and maintain normal potassium and magnesium. Reassess the combination if QTc lengthens.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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