Drug interactions
Primidone + Saxagliptin
Severity: Minor
Primidone and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly metabolized to phenobarbital, induces CYP3A4/5 and may lower saxagliptin exposure. The clinical consequence is probably small, but glucose control could be slightly reduced.
What this interaction means in plain words
Primidone and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Primidone belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
CYP3A4/5 induction by primidone and its phenobarbital metabolite increases saxagliptin clearance.
What to do
No empiric dose change; monitor blood glucose and HbA1c after starting or stopping primidone and adjust therapy if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Saxagliptin?
MediHelp rates the interaction as minor. Primidone and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone, partly metabolized to phenobarbital, induces CYP3A4/5 and may lower saxagliptin exposure. The clinical consequence is probably small, but glucose control could be slightly reduced.
How serious is the interaction between Primidone and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; monitor blood glucose and HbA1c after starting or stopping primidone and adjust therapy if control deteriorates.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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