Drug interactions
Probenecid + Sulindac
Severity: Moderate
Probenecid and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits the renal tubular secretion of sulindac and its active sulfide metabolite, which can raise NSAID exposure and the risk of NSAID adverse effects. Salicylate-type competition for urate handling is not the concern here, rather increased sulindac exposure.
What this interaction means in plain words
Probenecid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Sulindac belongs to Musculoskeletal.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule, reducing sulindac clearance.
What to do
Watch for NSAID adverse effects such as GI upset, edema and renal changes, and use the lowest effective sulindac dose. Reduce the sulindac dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Sulindac?
MediHelp rates the interaction as moderate. Probenecid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits the renal tubular secretion of sulindac and its active sulfide metabolite, which can raise NSAID exposure and the risk of NSAID adverse effects. Salicylate-type competition for urate handling is not the concern here, rather increased sulindac exposure.
How serious is the interaction between Probenecid and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for NSAID adverse effects such as GI upset, edema and renal changes, and use the lowest effective sulindac dose. Reduce the sulindac dose if toxicity appears.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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