Drug interactions
Probenecid + Sulphasalazine
Severity: Minor
Probenecid and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine and its metabolites are organic anions that may compete with probenecid for renal tubular secretion. The clinical effect is poorly characterised, but exposure to either drug could change modestly. The effect is unlikely to be significant in most patients.
What this interaction means in plain words
Probenecid and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Probenecid belongs to Genitourinary; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Possible competition for renal tubular anionic transport (OAT-mediated secretion); the clinical effect on uricosuric action is not well established.
What to do
No routine change is required. If gout control worsens or sulfasalazine adverse effects such as nausea or rash appear, reassess both doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Probenecid and Sulphasalazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Sulphasalazine?
MediHelp rates the interaction as minor. Probenecid and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine and its metabolites are organic anions that may compete with probenecid for renal tubular secretion. The clinical effect is poorly characterised, but exposure to either drug could change modestly. The effect is unlikely to be significant in most patients.
How serious is the interaction between Probenecid and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. If gout control worsens or sulfasalazine adverse effects such as nausea or rash appear, reassess both doses.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
