Drug interactions
Probenecid + Tolazamide
Severity: Moderate
Probenecid and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can reduce the renal elimination of sulfonylureas, raising their concentrations and prolonging their effect. This may cause hypoglycemia, especially in elderly patients or those with renal impairment.
What this interaction means in plain words
Probenecid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Tolazamide belongs to Endocrine.
Why it happens
Probenecid inhibits renal tubular secretion of the sulfonylurea or its active metabolites via organic anion transport, reducing clearance.
What to do
Monitor blood glucose when starting or stopping probenecid. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Probenecid with Tolazamide?
MediHelp rates the interaction as moderate. Probenecid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can reduce the renal elimination of sulfonylureas, raising their concentrations and prolonging their effect. This may cause hypoglycemia, especially in elderly patients or those with renal impairment.
How serious is the interaction between Probenecid and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping probenecid. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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