Drug interactions
Probenecid + Tolfenamic acid
Severity: Moderate
Probenecid and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal clearance of NSAIDs, so tolfenamic acid exposure may rise. This can increase gastrointestinal, renal and other NSAID-related adverse effects.
What this interaction means in plain words
Probenecid and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Probenecid competitively inhibits renal organic anion transporters (OAT1/OAT3) and may inhibit glucuronidation, reducing NSAID elimination.
What to do
Use the lowest effective tolfenamic acid dose and monitor for GI bleeding and renal toxicity. Reduce the NSAID dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Probenecid with Tolfenamic acid?
MediHelp rates the interaction as moderate. Probenecid and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal clearance of NSAIDs, so tolfenamic acid exposure may rise. This can increase gastrointestinal, renal and other NSAID-related adverse effects.
How serious is the interaction between Probenecid and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tolfenamic acid dose and monitor for GI bleeding and renal toxicity. Reduce the NSAID dose if adverse effects appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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