Drug interactions
Probenecid + Zidovudine
Severity: Moderate
Probenecid and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid increases zidovudine plasma concentrations and prolongs its half-life. This can increase hematologic toxicity and may cause rash, fever, or myalgia.
What this interaction means in plain words
Probenecid and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Zidovudine belongs to Anti Virals.
Why it happens
Probenecid inhibits zidovudine glucuronidation and renal tubular secretion, reducing clearance.
What to do
Monitor blood counts and for hypersensitivity-like symptoms. Consider reducing the zidovudine dose or avoiding the combination if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Probenecid with Zidovudine?
MediHelp rates the interaction as moderate. Probenecid and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid increases zidovudine plasma concentrations and prolongs its half-life. This can increase hematologic toxicity and may cause rash, fever, or myalgia.
How serious is the interaction between Probenecid and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for hypersensitivity-like symptoms. Consider reducing the zidovudine dose or avoiding the combination if toxicity develops.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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