Drug interactions
Procainamide + Trimipramine
Severity: Contraindicated
Procainamide and Trimipramine: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow conduction and can prolong the QT interval. Together they increase the risk of torsades de pointes and conduction block.
What this interaction means in plain words
Procainamide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive sodium channel blockade and QT prolongation.
What to do
Avoid the combination and choose alternatives. If unavoidable, use continuous ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Procainamide with Trimipramine?
MediHelp rates the interaction as contraindicated. Procainamide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs slow conduction and can prolong the QT interval. Together they increase the risk of torsades de pointes and conduction block.
How serious is the interaction between Procainamide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose alternatives. If unavoidable, use continuous ECG monitoring and correct electrolytes.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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