Drug interactions
Procarbazine + Quetiapine
Severity: Moderate
Procarbazine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibitor activity and also causes CNS depression, so it may add to quetiapine sedation and, rarely, contribute to serotonergic or hypotensive effects. The combination is not strongly documented.
What this interaction means in plain words
Procarbazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Weak MAO inhibition by procarbazine with additive CNS depression; serotonergic contribution is theoretical.
What to do
Monitor for excessive sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome such as hyperthermia, rigidity and altered mental status. Reduce the quetiapine dose if sedation is marked.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Quetiapine?
MediHelp rates the interaction as moderate. Procarbazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibitor activity and also causes CNS depression, so it may add to quetiapine sedation and, rarely, contribute to serotonergic or hypotensive effects. The combination is not strongly documented.
How serious is the interaction between Procarbazine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome such as hyperthermia, rigidity and altered mental status. Reduce the quetiapine dose if sedation is marked.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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